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Mirapex (Pramipexole) is truly a wonder, it takes away 99% of my symptoms if taken early evening. I've used it for 10 years or more now and it hasn't failed me until lately, as my dose is now at 1mg at night and 0.5mg in the morning. My symptoms do come up early enough to get me out of bed in the morning once in a rare while.

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I've been using Pramipexole for several years, gradually increasing the dosage over the years to 0.5 mg. I've found it to be somewhat effective although I still have some involuntary kicking in my sleep, and onset of restless legs while driving for extended periods.

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In the past few years, the symptoms have gotten worse.

They help decrease the rate of breakdown of levodopa, so more is available to work in the brain.

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